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Prior to the discovery of RNA interference (RNAi), in vitro knock-out of genes was technically troublesome and time-consuming work. Mostly, antisense molecules or ribozymes were used for it, but it often caused side effects and the results were not easy to interpret. RNAi is a mechanism of gene silencing at the mRNA level and offers a quick and effective approach for shutting off specific genes.

Especially synthetic small interfering RNA (siRNA) offers researchers an easy and consistent tool to manipulate genes in vitro. siRNA as a duplex is typically made of 19 bases with symmetric 2 nucleotide 3กฏ overhangs and can target any genes. Nowadays, the popularity of RNAi has increased rapidly as a tool for functional genomics and target validation, replacing the expensive transgenic animals for gene silencing experiments.

RNAi also has the potential to be used as a powerful therapeutic with high specificity. Two RNA-based drugs are already submitted for Phase I clinical study in the USA to cure age-related macular degeneration (AMD) and more are expected to follow this year.
ST Pharm. Co. Ltd. provides users with high quality and low priced RNAi by focusing our full resources on improving and evolving the manufacture of complex RNA-related molecules. Natural and modified small RNA is being synthesized under precise quality control with a focus on customer satisfaction.
  10 nmole
20 nmole
80 nmole
gram scale
Kilogram scale
  Desalted
HPLC purified
PAGE purified
Sterile, desalted (for vivo use)
Sterile, HPLC purified (for vivo use)
  Only CMO with fully-backward integrated manufacturing capabilities from amidites to oligonucleotides
US FDA audited and approved site for nucleoside API manufacturing with outstanding GMP compliance without
   any 483 citations
First commercial-scale GMP oligonucleotide production in Asia
Fully equipped lab for high-throughput synthesis of research-scale oligos
Non-GMP gram-scale oligo synthesis capabilities to compliment the GMP facilities
Experience in kilo-scale GMP production of Phase II oligo API
Ability to synthesize complex chemistry oligos: miRNA, siRNA, PS antisense, and PEG-Aptamers containing a
   variety of sugar modified amidites
In-house process R&D and full analytical support for oligo API manufacturing
Seamless transition from mg-scale to GMP-oligo